What Controls Tissue-specific Expression of the IL-4 Gene?
Identifieur interne : 000653 ( Main/Exploration ); précédent : 000652; suivant : 000654What Controls Tissue-specific Expression of the IL-4 Gene?
Auteurs : Min Li-Weber [Allemagne] ; Oskar Laur [Allemagne] ; Ilia V. Davydovv [États-Unis] ; Chenggan Hu [États-Unis] ; Padmini Salgame [États-Unis] ; Peter H. Krammer [Allemagne]Source :
- Immunobiology [ 0171-2985 ] ; 1997.
Abstract
Interleukin-4 (IL-4) plays a central role in the pathogenesis of allergic inflammation by inducing Ig class switch to IgE. IL-4 is also the most potent factor that drives naive T helper (Th) cells to differentiate to the Th2 phenotype. Recently, efforts have been made to explore the molecular basis of the Th2-specific IL-4 expressiom in CD4 T cells. Transcription factors, such as GATA-3, NF-IL6 and c-Maf, were found to be preferentially expressed in Th2 cells and to play an important role in regulation of the IL-4 promoter activity. Yet, other transcription factors may be indirectly involved in Th2-specific expression of IL-4 even though they are present in both Th1 and Th2 cells. In conclusion, Th2-specific expression of the IL-4 gene appears to be controlled by a multi-factor- system.
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DOI: 10.1016/S0171-2985(97)80038-1
Affiliations:
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Davydovv</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Present Address: Div. of Biology, 147-75, Caltech, Pasadena, CA 91125</wicri:regionArea><wicri:noRegion>CA 91125</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Chenggan" sort="Hu, Chenggan" uniqKey="Hu C" first="Chenggan" last="Hu">Chenggan Hu</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Salgame, Padmini" sort="Salgame, Padmini" uniqKey="Salgame P" first="Padmini" last="Salgame">Padmini Salgame</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Krammer, Peter H" sort="Krammer, Peter H" uniqKey="Krammer P" first="Peter H." last="Krammer">Peter H. Krammer</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Tumor Immunology Program, German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Immunobiology</title><title level="j" type="abbrev">IMBIO</title><idno type="ISSN">0171-2985</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997">1997</date><biblScope unit="volume">198</biblScope><biblScope unit="issue">1–3</biblScope><biblScope unit="page" from="170">170</biblScope><biblScope unit="page" to="178">178</biblScope></imprint><idno type="ISSN">0171-2985</idno></series><idno type="istex">2814A2BE16C5C143359AF57A08842B51AF95F692</idno><idno type="DOI">10.1016/S0171-2985(97)80038-1</idno><idno type="PII">S0171-2985(97)80038-1</idno><idno type="ArticleID">80038</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0171-2985</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Interleukin-4 (IL-4) plays a central role in the pathogenesis of allergic inflammation by inducing Ig class switch to IgE. IL-4 is also the most potent factor that drives naive T helper (Th) cells to differentiate to the Th2 phenotype. Recently, efforts have been made to explore the molecular basis of the Th2-specific IL-4 expressiom in CD4 T cells. Transcription factors, such as GATA-3, NF-IL6 and c-Maf, were found to be preferentially expressed in Th2 cells and to play an important role in regulation of the IL-4 promoter activity. Yet, other transcription factors may be indirectly involved in Th2-specific expression of IL-4 even though they are present in both Th1 and Th2 cells. In conclusion, Th2-specific expression of the IL-4 gene appears to be controlled by a multi-factor- system.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>États-Unis</li></country><region><li>Bade-Wurtemberg</li><li>District de Karlsruhe</li><li>Pennsylvanie</li></region><settlement><li>Heidelberg</li></settlement></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Li Weber, Min" sort="Li Weber, Min" uniqKey="Li Weber M" first="Min" last="Li-Weber">Min Li-Weber</name></region><name sortKey="Krammer, Peter H" sort="Krammer, Peter H" uniqKey="Krammer P" first="Peter H." last="Krammer">Peter H. Krammer</name><name sortKey="Laur, Oskar" sort="Laur, Oskar" uniqKey="Laur O" first="Oskar" last="Laur">Oskar Laur</name><name sortKey="Li Weber, Min" sort="Li Weber, Min" uniqKey="Li Weber M" first="Min" last="Li-Weber">Min Li-Weber</name></country><country name="États-Unis"><noRegion><name sortKey="Davydovv, Ilia V" sort="Davydovv, Ilia V" uniqKey="Davydovv I" first="Ilia V." last="Davydovv">Ilia V. Davydovv</name></noRegion><name sortKey="Hu, Chenggan" sort="Hu, Chenggan" uniqKey="Hu C" first="Chenggan" last="Hu">Chenggan Hu</name><name sortKey="Salgame, Padmini" sort="Salgame, Padmini" uniqKey="Salgame P" first="Padmini" last="Salgame">Padmini Salgame</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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